Transfusion medicine handbook

5. Fractionated Products

5.1.3 Beriplex NZ

Beriplex NZ is presented as a powder, containing human prothrombin complex, in packs of 500 IU Factor IX, for reconstitution with a vial of diluent (Water for Injections). It is made from New Zealand plasma. It contains up to 343 mg (approximately 15 mmol) sodium and up to 200 IU heparin per 100 mL reconstituted solution.

• Beriplex NZ has the following coagulation factor content per vial [1]:
• Factor II, 400 – 960 IU
• Factor VII, 200 – 500 IU
• Factor IX, 400 – 620 IU
• Factor X, 440 – 1200 IU
• Protein C, 300 – 900 IU
• Protein S, 240 – 760

It should be noted that Beriplex NZ is a ‘4 factor’ prothrombin complex concentrate compared to Prothrombinex-VF which is a ‘3 factor’ product. Furthermore, Beriplex NZ contains Protein C and Protein S.

Indications for Use

• Beriplex NZ is indicated for the treatment and perioperative prophylaxis of bleeding in acquired deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists, or in case of overdose of vitamin K antagonists, when rapid correction of the deficiency is required.

Further information to be provided.